Sivapriya Kirubakaran
Department : Chemistry
Research Interests
● Drug discovery and cancer chemical biology
● Use of small molecules to study cancer related proteins
● Basic synthetic organic chemistry
Professional Summary
Associate Professor, Indian Institute of Technology, Gandhinagar (Feb 2020 to Present)
Assistant Professor, Indian Institute of Technology, Gandhinagar (Jan 2013 to Feb 2020)
Postdoctoral Fellow, Dana Farber Cancer Institute, Harvard Medical School (Jan 2010 – Dec 2012)
Visiting Scientist: Whitehead Institute, MIT (Jan 2010 – June 2011)
Postdoctoral Fellow, Brigham and Women’s Hospital, Harvard Medical School and Brandeis University (Oct 2007 – Dec 2009)
Publications
1. Juvale, K.*; Purushothaman, G.*; Singh, V.; Shaik, A.; Ravi, S.;Thiruvenkatam, V.; Kirubakaran, S., Identification of selective inhibitors of Helicobacter pylori IMPDH as a targeted therapy for the infectionScientific Reports, 2019 9:190. DOI: 10.1038/s41598-018-37490-x (* Equal first authors).
2. Bhakuni, R.; Shaik, A.; Kirubakaran, S., Evaluation of MBP tagged-hATR kinase domain catalytic activity with p53 Ser-15 phosphorylation. Biochemistry, 2018, 57, 47, 6592-6603.
3. Shaik, A.; Bhakuni, R.; Kirubakaran, S., Design, Synthesis, and Docking Studies of New Torin2 Analogs as Potential ATR/mTOR Kinase Inhibitors. Molecules 2018, 23 (5), 992.
4. Bhoir, S.; Shaik, A.; Thiruvenkatam, V. *; Kirubakaran, S. *, High yield bacterial expression, purification and characterisation of bioactive Human Tousled-like Kinase 1B involved in cancer. Scientific Reports 2018, 8 (1), 4796. (* Equal Corresponding authors).
Complete List of Publications
Patents
ATM Inhibitors pharmaceutical composition and process for preparing the same: Kirubakaran, Sivapriya; Ravi Srimadhavi, Shaik, Althaf and Sugata Barui: Indian Patent Office, Patent Application No.: 201821039653, Oct 19, 2018
Kirubakaran, Sivapriya; Thiruvenkatam, Vijay; Hussain, Javeena; Purushothaman Gayathri and Bhoir, Siddhant, “Phosphate derivatives of Myo-Inositol as RAS inhibitors”, Indian Patent Office, Patent Application No.: 201721020827, Jun. 14, 2017
Pharmaceutical composition and process for preparing the same: Kirubakaran, Sivapriya; Thiruvenkatam, Vijay; Juvale, Kapil; Singh, Vijay; Purushothaman, Gayathri and Shaik, Althaf, Indian – Patent Office, Patent Application No.: 201621024723, Jul. 19, 2016
Substituted 1,2-Dihydro- 3H-Pyrazolo[4,3-C]Quinolin- 3- One as ATR Kinase Inhibitors: Kirubakaran, Sivapriya; Thiruvenkatam,Vijay; Shaik, Althaf and Bhakuni, Rashmi, Indian Patent Office, Patent Application No.: 201621026397, Aug. 2, 2016
Novel compounds for treating H pylori infection and related gastric cancer: Pharmaceutical composition and process for preparing the same: Kirubakaran Sivapriya; Thiruvenkatam, Vijay; Juvale, Kapil; Singh, Vijay; Purushothaman, Gayathri and Shaik, Althaf”Indian Patent Office, Patent Application No.: 201621024723, Jul. 19, 2016
COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTRO INTESTINAL & MICROBIAL INFECTIONS: United States application or PCT international application number 14/571,673, Date of publication: 16/12/2014. Inventors: Sivapriya Kirubakaran* & Lizbeth Hedstrom, Deviprasad Gollapalli, Greg Cuny, Suresh Gorla, Jihan Khan
Compounds for treating mammalian gastrointestinal microbial infections, European Patent Application EP2408753, Lizbeth K Hedstrom, Gregory D Cuny, Deviprasad R Gollapalli, Sivapriya Kirubakaran, Boris Striepen, Suresh Kumar Gorla, Sushil K Maurya, Corey Robert Johnson, Mandapati Kavitha, Jihan Khan, Publication date: 25/1/2012