Sharad Gupta
Department : Biological Engineering
Research Interests
● Protein aggregation and their role in neurodegenerative disorders
● Role of post translational modifications on protein aggregation and toxicity
● Peptides as molecular probes / therapeutics in Alzheimer’s disease and related disorders
● Role of proteomics in understanding the effect of disease modifying therapies
● Difficult peptide synthesis and novel scaffolds
Professional Summary
Associate Professor, Indian Institute of Technology Gandhinagar (Feb 2019 to present)
Assistant Professor, Indian Institute of Technology Gandhinagar (July 2012 to Jan 2019)
Post Doctoral Fellow, Department of Chemical and Biomolecular Engineering, University of Delaware (Aug 2010 – June 2012)
Post Doctoral Researcher, Department of Chemistry, Temple University (Sept 2009-July 2010)
Publications
Joshna Gadhavi, Sumedha Shah, Tulika Sinha, Alok Jain and Sharad Gupta, “Charge neutralization of lysine via carbamylation reveals hidden aggregation hot-spots in tau protein flanking regions” The FEBS Journal, 2021, https://doi.org/10.1111/febs.16284
Chinmaya Panda, Clara Voelz, Pardes Habib, Christian Mevissen, Thomas Pufe, Cordian Beyer, Sharad Gupta, Alexander Slowik*, “Aggregated tau-PHF6 (VQIVYK) potentiates NLRP3 inflammasome expression and autophagy in human microglial cells” Cells 2021, 10(7), 1652; https://doi.org/10.3390/cells10071652,
Hivare, Pravin; Rajwar, Anjali; Gupta, Sharad and Bhatia, Dhiraj, “Spatiotemporal dynamics of endocytic pathways adapted by small DNA nanocages in model neuroblastoma cell-derived differentiated neurons”, ACS Applied Bio Materials, 2021, DOI: 10.1021/acsabm.0c01668.
Marapureddy, Sai Geetha; Hivare, Pravin; Sharma, Aarushi; Chakraborty, Juhi; Ghosh, Sourabh; Gupta, Sharad and Thareja, Prachi, “Rheology and direct write printing of chitosan – graphene oxide nanocomposite hydrogels for differentiation of neuroblastoma cells”, Carbohydrate Polymers, 2021, DOI: 10.1016/j.carbpol.2021.118254, vol. 269.
Hivare, Pravin; Panda, Chinmaya; Gupta, Sharad and Bhatia, Dhiraj, “Programmable DNA nanodevices for applications in neuroscience”, ACS Chemical Neuroscience, 2021, DOI: 10.1021/acschemneuro.0c00723.
Mudasir Maqbool, Joshna Gadhavi, Pravin Hivare, Sharad Gupta and Nasimul Hoda, “Diphenyl triazine hybrids inhibit α-synuclein fibrillogenesis: Design, synthesis and in vitro efficacy studies” European Journal of Medicinal Chemistry, 2020, DOI: 10.1016/j.ejmech.2020.112705, vol. 207, 112705.
Guru Krishnakumar, V.; Baweja, Lokesh; Ralhan, Krittika and Gupta, Sharad, “Carbamylation promotes amyloidogenesis and induces structural changes in Tau-core hexapeptide fibrils”, Biochimica et Biophysica Acta (BBA) – General Subjects, 2018, DOI: 10.1016/j.bbagen.2018.07.030, Vol.1862, No.12, pp. 2590-2604.
Ralhan, K.; Guru Krishna Kumar, V.; Gupta. S. “Piperazine and DBU: a safer alternative for rapid and efficient fmoc deprotection in solid phase peptide synthesis.” RSC Advances,2015, 5, 104417-104425. DOI: 10.1039/C5RA23441G.