Chandrakumar Appayee
Department : Chemistry
Research Interests
● Development of novel double-hydrogen bond donor catalysts
● Asymmetric amine catalysis
● Asymmetric synthesis of bio-active molecules
● Study of small molecules for targeted diseases
Professional Summary
Associate Professor, Indian Institute of Technology, Gandhinagar (Feb 2020 to Present)
Assistant Professor, Indian Institute of Technology, Gandhinagar (Dec 2013 to Feb 2020)
Postdoctoral Research Scientist, Columbia University, New York, (Jun 2012 – Dec 2013)
Postdoctoral Research Associate, Brooklyn College and the City University of New York, (July 2009 – Jun 2012)
Postdoctoral Research Associate, University of Miami, Florida, (July 2008 – Jun 2009)
Publications
1. Sarkale, A. M.; Appayee, C.* “Stereodivergent Synthesis of 1-Hydroxymethylpyrrolizidine Alkaloids” rg. Lett. 2020, Article ASAP.
2. Kutwal, M. S.; Padmaja, V. M. D.; Appayee, C.* “Regio‐and Enantioselective α,γ‐Dialkylation of α,β‐Unsaturated Aldehydes through Cascade Organocatalysis” Eu. J. Org. Chem. 2020, 2720-2724. (Invited Article for a themed collection “YourJOC Talent”)
3. Maurya, V.; Appayee, C.* “Enantioselective Total Synthesis of Potent 9β-11-Hydroxyhexahydrocannabinol” J. Org. Chem. 2020, 85, 1291-1297.
4. Sarkale, A. M.; Maurya, V.; Giri, S.; Appayee, C.* “Stereodivergent Synthesis of Chiral Paraconic Acids via Dynamic Kinetic Resolution of 3-Acylsuccinimides” Org. Lett. 2019, 21, 4266-4270.
5. Kutwal, M. S.; Dev, S; Appayee, C.* “Catalytic Regioselective γ-Methylenation of α,β-Unsaturated Aldehydes Using Formaldehyde via Vinylogous Aldol Condensation” Org. Lett. 2019, 21, 2509-2513. (Among the most downloaded articles in April 2019 and also highlighted in Synfacts 2019, 15, 0797.)
6. Padmaja, V. M. D.; Jangra, S.; Appayee, C.* “Highly Regioselective α-Alkylation of α,β,γ,δ-Unsaturated Aldehydes” Org. Biomol. Chem. 2019, 17, 1714–1717. (Invited Article for a themed collection “New Talent”)
Complete List of Publications
Patents
1. Appayee, C.; Padmaja, V. M. D.; Kutwal, M. S. “Photochromic organic compounds and a process for preparation thereof”. Indian Patent, Application No. 202021012831.
2. Appayee, C.; Padmaja, V. M. D. “Photochromic organic compounds and a process for preparation thereof”.Indian Patent, Application No. 202021012829.
3. Appayee, C.; Sarkale, A. M. “Method for the asymmetric synthesis of (S)-paraconic acid”. Indian Pat. Appl. (2019), IN 201721019540 A 20190712.