Vijay Thiruvenkatam
Department : Biological Engineering
Research Interests
● Structural biology of macromolecular complexes
● Chemical crystallography
● Insitu cryo-crystallizations of liquids
● Projects: a) Structural investigation of Alzheimer disease related protein gamma secretase activating protein (GSAP) b) Structural investigation of (Ataxia telangiectasia and Rad3-related protein) ATR and (Ataxia telangiectasia mutated) ATM Kinase protein
Professional Summary
Associate Research Professor, Indian Institute of Technology Gandhinagar (Nov 2021 to present)
Assistant Research Professor, Indian Institute of Technology Gandhinagar (Jan 2013 – Nov 2021)
Postdoctoral Researcher, Beth Israel Deaconess Medical School/Harvard Medical School(June 2011 – Dec 2012)
Postdoctoral Researcher, BU/DFCI/Harvard Medical School (Sep 2009 – May 2011)
Publications
1. Identification of selective inhibitors of Helicobacter pylori IMPDH as a targeted therapy for the infection; Kapil Juvale1,4,#, Gayathri Purushothaman2,#, Vijay Singh2, Althaf Shaik1, Srimadhavi Ravi1, Vijay Thiruvenkatam2,3, Sivapriya Kirubakaran1,2* Scientific Reports, 2018 (Accepted) (IF 4.12).
2. Exploring solvated dimer of Gefitinib: A quantitative analysis Deekshi Angira, Althaf Shaik, Sivapriya Kirubakaran and Vijay Thiruvenkatam*, Acta Crystallographica Section C: Structural Chemistry, C74, 944-950, 2018 (IF 8.67).
3. A quantitative and qualitative analysis of intermolecular interactions in substituted xanthenedione derivatives; Gayathri Purushothaman and Vijay Thiruvenkatam*, Acta Crystallographica Section C: Structural Chemistry, 74, 7, 2018 (IF 8.67).
4. High yield bacterial expression, purification and characterisation of bioactive Human Tousled-like Kinase 1B involved in cancer; Siddhant Bhoir, Vijay Thiruvenkatam#, Sivapriya Kirubakaran*, Scientific Reports, 8 (1), 4796, 2018 (IF 4.12).
5. Design, synthesis, and biological evaluation of Helicobacter pylori inosine 5-monophosphate dehydrogenase (HpIMPDH) inhibitors Niteshkumar U. Sahu1, Gayathri Purushothaman2, Vijay Thiruvenkatam2,3, Prashant S. Kharkar1 Drug Development Research, 1-8, 2018 (IF 2.646).
6. Role of =NOH intermolecular interactions in oxime derivatives via Crystal structure, Hirshfeld surface, PIXELC and DFT calculations, Gayathri Purushothaman, Vijay Thiruvenkatam; Journal of Molecular Structure; 1148, 371-380, 2017 (IF 2.01).
Complete List of Publications
Patents
Phosphate derivatives of Myo-Inositol as RAS inhibitors”, Kirubakaran, Sivapriya; Thiruvenkatam, Vijay; Hussain, Javeena; Purushotaman Gayathri and Bhoir,Siddhant, Indian Patent Office, Patent Application No.:201721020827, Jun. 14, 2017
Pharmaceutical composition and process for preparing the same: Kirubakaran, Sivapriya; Thiruvenkatam, Vijay; Juvale, Kapil; Singh, Vijay; Purushothaman, Gayathri and Shaik, Althaf, Indian Patent Office, Patent Application No.: 201621024723, Jul. 19, 2016
Substituted 1,2-Dihydro- 3H-Pyrazolo[4,3-C]Quinolin- 3- One as ATR Kinase Inhibitors: Kirubakaran, Sivapriya; Thiruvenkatam, Vijay; Shaik, Althaf and Bhakuni, Rashmi, Indian Patent Office, Patent Application No.: 201621026397, Aug. 2, 2016